Concepts and Core Principles of Fragment-Based Drug Design
نویسندگان
چکیده
منابع مشابه
“Fragment-Based Drug Design of Bromodomain Ligands”
Epigenetic mechnisms are essential for normal development and alterations of epigenetic processe are correlated with many human diseases, e.g., cancer. One of the important epigenetic modifications, acetylation of lysine, is mainly recognized by structurally conserved protein module bromodomains. Targeting bromodomains by small molecules is an emerging therapeutic strategy for cancer treatment....
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متن کاملDrug Interactions with Antiretroviral Medications - Core Concepts
Pharmacokinetic and pharmacodynamics principles are fundamental to achieving the optimal response to antiretroviral drug therapy: successful antiretroviral therapy depends on attaining a therapeutic drug concentration that maximizes efficacy and minimizes toxicity.[1] Understanding drug interactions plays an important role for clinicians in providing effective and safe antiretroviral therapy. D...
متن کاملDrug Interactions with Antiretroviral Medications - Core Concepts
Pharmacokinetic and pharmacodynamics principles are fundamental to achieving the optimal response to antiretroviral drug therapy: successful antiretroviral therapy depends on attaining a therapeutic drug concentration that maximizes efficacy and minimizes toxicity.[1] Understanding drug interactions plays an important role for clinicians in providing effective and safe antiretroviral therapy. D...
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ژورنال
عنوان ژورنال: Molecules
سال: 2019
ISSN: 1420-3049
DOI: 10.3390/molecules24234309